يستعمل دواء ميجورا 5مجم/500مجم 20 اقراصmigaura 5mg/500mg 20 tab. antiemetic antiemetic

about metoclopramide -it is a dopamine antagonist - antiemetic gastroprokinetic agent. -mechanism of action of metoclopramide -metoclopramide acts through both serotonergic and dopaminergic receptors. metoclopramide binds to serotonin (5 ht3 &5ht4) and dopamine (d2) receptor. -antiemetic action: metoclopramide inhibits dopamine receptor in the chemoreceptor trigger zone and produces antiemetic action. -intestinal motility modifying action: the binding of metoclopramide on 5ht4 receptor will activate interneuron and enhance the release of acetylcholine innervating the smooth muscles. this produces gastric emptying and enhances lower esophageal sphincter tone. -migraine: metoclopramide is used in migraine to relieve nausea and vomiting -anaesthetic adjuncts: it is used preoperatively in order to reduce the post operative vomiting.