يستعمل دواء دانترون 50 مجم 10 كبسولاتdantrone 50 mg 10 caps. skeletal muscle relaxant.analgesic.ryanodine receptor (ryr1) calcium channel blocker peripheral skeletal muscle relaxant.analgesic.ryanodine receptor (ryr1) calcium channel blocker peripheral

mechanism of action of dantrolene sodium -dantrolene is s skeletal muscle relaxant which differs from the classical neuromuscular blocking drugs. it inhibits the release of calcium from sarcoplasmic reticulam and suppresses excitation contraction coupling. it reduces the calcium level associated with malignant hyperthermia crises. - -indications for dantrolene sodium -1. spasticity resulting from upper motor neuron lesions such as spinal cord injury stroke multiple sclerosis cerebral palsy -typical dosage for dantrolene sodium -oral -adult: 25mg/day if needed dose can be increased by 25mg every 4 - 7 days up to 400mg/day in 4 divided doses. -children -above 5 years: 0.5mg/kg 2 times daily if needed dose can be gradually increased by 0.5mg/kg up to 3mg/kg 2 - 4 times daily. maximum dose: 400 mg/day