يستعمل دواء سيليبورج 200 مجم 20 كبسولةceleborg 200 mg 20 caps. nsaid.selective cox-2 inhibitors nsaid.selective cox-2 inhibitors

about celecoxib -non-steroidal anti inflammatory drug (nsaid) cox-2 selective inhibitor anti-inflammatory agent. - -mechanism of action of celecoxib -this inhibits prostaglandin synthesis peripherally by selective noncompetitive inhibition of cyclooxygenase-2 (cox-2) enzyme. it binds with its polar sulfonamide side chain to a hydrophilic side pocket region close to the active cox-2 binding site (both cox-1 and cox-2 catalyze the conversion of arachidonic acid to prostaglandin (pg) h2 the precursor of pgs and thromboxane). this results its anti-inflammatory action - -indications for celecoxib -1. osteoarthritis -2. rheumatoid arthritis -3. acute gout - -contra-indications of celecoxib -1. hypersensitivity to celecoxib -2. allergic type reactions to sulphonamides /aspirin or other nsaids.