يستعمل دواء سايمزيت 10/10مجم 14 اقراصsimezet 10/10 mg 14 tab. antihyperlipidemic.cholesterol absorption inhibitors.combined with statin antihyperlipidemic.cholesterol absorption inhibitors.combined with statin

ezetimibe+simvastatin - -about ezetimibe -cholesterol absorption inhibitor 2-azetidinone derivative hypolipidemic agent. -mechanism of action of ezetimibe -it reduces the absorption of cholesterol from the intestine by localising at the brush border of the small intestine where it inhibits the absorption of cholesterol from the diet. specifically it appears to bind to the niemann-pick c1-like 1 (npc1l1) protein on the gastrointestinal tract epithelium a critical mediator of cholesterol absorption. this decreased cholesterol absorption leads to an increase in ldl-cholesterol uptake into cells thus decreasing levels in the blood plasma. -indications for ezetimibe -1. adjunct to dietary measures and statin in primary and homozygous familial hypercholesterolaemia -2. adjunct to dietary measures in homozygous familial sitosterolaemia -interactions for ezetimibe -cyclosporin: plasma concentraction of ezetimibe increased. lipid-regulating drugs: avoid concomitant use with fibrates.