يستعمل دواء سانديمون نيورال 25مجم 50 كبسولsandimmun neoral 25 mg 50 s.g.caps. immunosuppressant immunosuppressant

about cyclosporin a -a cyclic nonribosomal peptide(11 amino acids) immunosuppressant drug organ transplant rejection prevention. - -mechanism of action of cyclosporin a -cyclosporine binds to the cytosolic protein cyclophilin (immunophilin) of immunocompetent lymphocytes especially t-lymphocytes. this complex inhibits calcineurin which is responsible for activating the transcription of interleukin 2. it also inhibits lymphokine production and interleukin release and therefore leads to reduced function of effecter t-cells. drug prevents mitochondrial pt pore from opening and inhibits cytochrome c release and also apoptosis induced by it. - -indications for cyclosporin a -1. organ transplant rejection -2. rheumatoid arthritis -3. crohn`s syndrome -4. nephrotic syndrome -5. psoriasis -6. ulcerative colitis -7. uveitis -8. neuroprotection in traumatic brain injury -9. aplastic anemia -10. myasthenia gravis -11. dermatomyositis